Cardiovascular album

Angiotensin Ⅱ is the renin - angiotensin system has significant biological activity of bioactive peptides, it has all the body organs from a variety of different levels of effect. Angiotensin Ⅱ systemic small artery contraction can rise high blood pressure , in addition, also promote the adrenal cortex to secrete aldosterone effect on tubules , from the security of sodium, water, row potassium, causing increased blood volume, blood pressure.
The researchers purified the AT1 receptor and the islet insulin immune fluorescence double detected; using different doses of vascular tight Su-Ⅱ study of human pancreatic islet insulin release its response to the impact. Results Immunofluorescence double labeling AT1 receptors in pancreatic islets and insulin staining were strongly positive, angiotensin Ⅱ on high glucose stimulated insulin secretion in a dose dependent inhibitory effect, with the AT1 receptor antagonist, can antagonize insulin pretreatment Inhibitory effect.Shows the existence of human islet isolation and purification of the AT1 receptor, angiotensin ⅡAT1 receptor through direct inhibition of islet insulin release response.
Angiotensin Ⅱreceptor antagonism has already found its Prototype drugs that saralasin. For IT can only peptide intravenous Injection, and its clinical applications are its Half-Life of the Inner Part of the short and exciting role which is limited. Indeed vascular tight Su- Ⅱ has become the effort management system, blood pressure regulation of Health Management of the key factors, so its corresponding receptor antagonism has become a As it should be the therapeutic approach.