Something about Adenine

Adenine was also called Vitamin B4.It is no longer considered a true vitamin or part of the Vitamin B complex. However, two B vitamins, niacin and riboflavin, bind with adenine to form the essential cofactors nicotinamide adenine dinucleotide and flavin adenine dinucleotide , respectively. Hermann Emil Fischer was one of the early scientists to study Adenine.Some think that, at the origin of life on Earth, the first adenine was formed by the polymerization of five hydrogen cyanide molecules. However, this has been criticized by some chemists.

Preparation of Adenine: this chemical can be derived from the nucleotide inosine monophosphate (IMP) by using atoms from the amino acids glycine, glutamine, and aspartic acid, as well as fused with the enzyme tetrahydrofolate. Additionally, you can use 4,6-Dichloro-5-nitropyrimidine to produce 4,6-Diamino-5-nitropyrimidine by reaction with Ammonia. And then you would obtain this chemical by the cyclization of 4,6-Diamino-5-nitropyrimidine with Formamide, Formic acid and Sodium thiosulfate.

Uses of Adenine: this chemical is used in forming nucleotides of the nucleic acids. Furthermore, it can bind to Thymine via two hydrogen bonds to assist in stabilizing the nucleic acid structures in DNA. And it is used for protein synthesis, adenine binds to uracil in RNA. It also can be used to produce Adenosine, Adenosine triphosphate (ATP). Similarly, it can react with Fluoromethyl-oxirane to get 1-(6-Amino-purin-9-yl)-3-fluoro-propan-2-ol.